Motor end-plate ‘desensitization’ by repetitive nerve stimuli

Substructure of Amphibian Motor End Plate

End-plate membrane has been examined at amphibian myoneural junctions by means of transmission electron microscopy of thin tissue sections. The postjunctional membrane exhibits morphologically specialized dense, convex patches which are located superficially facing the axon terminal but do not extend into the depths of the junctional folds. In the specialized regions the plasma membrane is appr...

The pattern of somatic response during a repetitive motor task and its modification by visual stimuli.

Human motor end plate: some ultrastructural aspects of its development.

Regarding the motor end plates, the earliest evidence of the formation of such structures was observed in the muscle of foetuses of nine and ten weeks development. At this stage the developing motor end plate consits of several small axons covered on their outer aspect by Schwann cell cytoplasm, while on the inner aspect they are separated by a layer of basement membrane of the myotube with whi...

Cholinesterase activity of motor end plate in human skeletal muscle.

The activity and properties of cholinesterase of the motor end plate in human intercostal muscle were studied in the isolated muscle membrane. This preparation was used because cholinesterase activity of the membrane preparation was localized in the motor end plate without contamination of cholinesterase of other muscle components. Under the experimental conditions, cholinesterase in a human en...

Altered motor nerve excitability in end-stage kidney disease.

Although multiple toxins have been implicated in the development of uraemic neuropathy, no causative agent has been identified. In the present study, the excitability properties of lower limb motor nerves in patients with end-stage kidney disease treated with haemodialysis were measured before, during and after a standard 5 h haemodialysis session, in an attempt to explore the pathophysiology o...